Found 236 hits of ic50 data for polymerid = 50000969,50002691 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50306490
((+)-(S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)Show SMILES CCCCCOC(=O)C1=C(C)N=C(C)C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OC |r,c:8,t:11| Show InChI InChI=1S/C21H26N2O6/c1-5-6-7-11-29-21(25)18-14(3)22-13(2)17(20(24)28-4)19(18)15-9-8-10-16(12-15)23(26)27/h8-10,12,17,19H,5-7,11H2,1-4H3/t17?,19-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description
Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac membrane |
Bioorg Med Chem Lett 20: 805-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.104
BindingDB Entry DOI: 10.7270/Q26D5T3S |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50029417
(CHEMBL277363 | [4-(4-Methoxy-phenyl)-4H-benzo[b]py...)Show InChI InChI=1S/C21H22N2OS/c1-22(2)14-16-10-13-19-21(15-8-11-17(24-3)12-9-15)25-20-7-5-4-6-18(20)23(16)19/h4-13,21H,14H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]nitrendipine from calcium channel receptor |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F47RB8 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50306489
((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)Show SMILES CCCCCOC(=O)C1=C(C)N=C(C)C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OC |r,c:8,t:11| Show InChI InChI=1S/C21H26N2O6/c1-5-6-7-11-29-21(25)18-14(3)22-13(2)17(20(24)28-4)19(18)15-9-8-10-16(12-15)23(26)27/h8-10,12,17,19H,5-7,11H2,1-4H3/t17?,19-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description
Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac membrane |
Bioorg Med Chem Lett 20: 805-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.104
BindingDB Entry DOI: 10.7270/Q26D5T3S |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50469633
(CHEMBL21906)Show InChI InChI=1S/C17H15NOS/c19-16-11-10-14-17(12-6-2-1-3-7-12)20-15-9-5-4-8-13(15)18(14)16/h1-9,14,17H,10-11H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]nitrendipine from calcium channel receptors (CCRs) from rat cortex homogenate |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80337-1
BindingDB Entry DOI: 10.7270/Q2F47RV0 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50103634
(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)Show SMILES COC(=O)C1=C(NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C)C#N |c:8,t:4| Show InChI InChI=1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3 | PDB
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PC cid
PC sid
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| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortex |
J Med Chem 32: 2399-406 (1989)
BindingDB Entry DOI: 10.7270/Q2GH9M57 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101813
(CHEBI:31399 | Cilnidipine)Show SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\C=C\c1ccccc1 |c:7,12| Show InChI InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+ | PDB
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| Article
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| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus method |
Bioorg Med Chem Lett 18: 4813-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.096
BindingDB Entry DOI: 10.7270/Q208684R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101813
(CHEBI:31399 | Cilnidipine)Show SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\C=C\c1ccccc1 |c:7,12| Show InChI InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+ | PDB
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PC cid
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| Article
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| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101813
(CHEBI:31399 | Cilnidipine)Show SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\C=C\c1ccccc1 |c:7,12| Show InChI InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+ | PDB
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| Article
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| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto Pharmaceuticals Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Voltage-dependent L-type calcium channel in rat thoracic aorta ring |
Bioorg Med Chem Lett 21: 3317-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.007
BindingDB Entry DOI: 10.7270/Q2N019CJ |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50306490
((+)-(S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)Show SMILES CCCCCOC(=O)C1=C(C)N=C(C)C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OC |r,c:8,t:11| Show InChI InChI=1S/C21H26N2O6/c1-5-6-7-11-29-21(25)18-14(3)22-13(2)17(20(24)28-4)19(18)15-9-8-10-16(12-15)23(26)27/h8-10,12,17,19H,5-7,11H2,1-4H3/t17?,19-/m0/s1 | PDB
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B.MOAD
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.48 | n/a | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description
Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cerebral cortex membrane |
Bioorg Med Chem Lett 20: 805-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.104
BindingDB Entry DOI: 10.7270/Q26D5T3S |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229256
(CHEMBL73590)Show SMILES CCO\C(O)=C1\C(C(C(=O)OCC)=C(C)N=C1CSc1ccccc1)c1ccccc1C(F)(F)F |c:15,t:12| Show InChI InChI=1S/C26H26F3NO4S/c1-4-33-24(31)21-16(3)30-20(15-35-17-11-7-6-8-12-17)23(25(32)34-5-2)22(21)18-13-9-10-14-19(18)26(27,28)29/h6-14,22,32H,4-5,15H2,1-3H3/b25-23+ | PDB
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UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101817
(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 | PDB
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B.MOAD
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DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
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| PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain. |
J Med Chem 31: 1659-64 (1988)
BindingDB Entry DOI: 10.7270/Q2WQ060D |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227967
(CHEMBL78973)Show SMILES CC(C)OC(=O)C1=C(C)N=C(C)N(C1c1ccccc1[N+]([O-])=O)C(=O)OCCN(Cc1ccccc1)Cc1ccc(Cl)c(Cl)c1 |c:6,t:9| Show InChI InChI=1S/C33H34Cl2N4O6/c1-21(2)45-32(40)30-22(3)36-23(4)38(31(30)26-12-8-9-13-29(26)39(42)43)33(41)44-17-16-37(19-24-10-6-5-7-11-24)20-25-14-15-27(34)28(35)18-25/h5-15,18,21,31H,16-17,19-20H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]- Nitrendipine binding to L-type calcium channels of rat cerebral cortex |
J Med Chem 32: 2399-406 (1989)
BindingDB Entry DOI: 10.7270/Q2GH9M57 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101817
(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 | PDB
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| Purchase
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MCE
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortex |
J Med Chem 32: 2399-406 (1989)
BindingDB Entry DOI: 10.7270/Q2GH9M57 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101817
(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 | PDB
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PC cid
PC sid
UniChem
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| Article
| n/a | n/a | 2.57 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of L-type calcium channel in Rattus norvegicus Wistar (rat) thoracic aorta assessed as relaxation of KCl-induced vasoconstriction after 30... |
Citation and Details
Article DOI: 10.1007/s00044-011-9600-x
BindingDB Entry DOI: 10.7270/Q2XS5Z80 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101817
(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 | PDB
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| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of L-type calcium channel in Rattus norvegicus Wistar (rat) thoracic aorta assessed as relaxation of KCl-induced vasoconstriction after 30... |
Citation and Details
Article DOI: 10.1007/s00044-011-9600-x
BindingDB Entry DOI: 10.7270/Q2XS5Z80 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101815
(CHEBI:7550 | Nicardipine)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1 |c:4,9| Show InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3 | PDB
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Similars
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortex |
J Med Chem 32: 2399-406 (1989)
BindingDB Entry DOI: 10.7270/Q2GH9M57 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475660
(CHEMBL201566)Show SMILES C\C(CO\C(O)=C1\C(C(C(O)=O)=C(C)N=C1C)c1cccc(Cl)c1)=C/c1ccccc1 |c:14,t:11| Show InChI InChI=1S/C25H24ClNO4/c1-15(12-18-8-5-4-6-9-18)14-31-25(30)22-17(3)27-16(2)21(24(28)29)23(22)19-10-7-11-20(26)13-19/h4-13,23,30H,14H2,1-3H3,(H,28,29)/b15-12+,25-22+ | PDB
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| PC cid
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| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50306489
((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)Show SMILES CCCCCOC(=O)C1=C(C)N=C(C)C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OC |r,c:8,t:11| Show InChI InChI=1S/C21H26N2O6/c1-5-6-7-11-29-21(25)18-14(3)22-13(2)17(20(24)28-4)19(18)15-9-8-10-16(12-15)23(26)27/h8-10,12,17,19H,5-7,11H2,1-4H3/t17?,19-/m1/s1 | PDB
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| CHEMBL
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UniChem
Similars
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PubMed
| n/a | n/a | 3.62 | n/a | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description
Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cerebral cortex membrane |
Bioorg Med Chem Lett 20: 805-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.104
BindingDB Entry DOI: 10.7270/Q26D5T3S |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475658
(CHEMBL201984)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\C1CCCCC1)c1cccc(Cl)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H28ClNO4/c1-15-20(23(27)28)22(18-11-6-12-19(25)14-18)21(16(2)26-15)24(29)30-13-7-10-17-8-4-3-5-9-17/h6-7,10-12,14,17,22,29H,3-5,8-9,13H2,1-2H3,(H,27,28)/b10-7+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475653
(CHEMBL382528)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccc(Cl)cc1)c1cccc(Cl)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H21Cl2NO4/c1-14-20(23(28)29)22(17-6-3-7-19(26)13-17)21(15(2)27-14)24(30)31-12-4-5-16-8-10-18(25)11-9-16/h3-11,13,22,30H,12H2,1-2H3,(H,28,29)/b5-4+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475650
(CHEMBL203041)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccc(C)cc1)c1cccc(Cl)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C25H24ClNO4/c1-15-9-11-18(12-10-15)6-5-13-31-25(30)22-17(3)27-16(2)21(24(28)29)23(22)19-7-4-8-20(26)14-19/h4-12,14,23,30H,13H2,1-3H3,(H,28,29)/b6-5+,25-22+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50479255
(CHEMBL453084)Show SMILES CCC1=C(C(C(C(O)=O)=C(C)N1)c1cccc(Cl)c1)C(=O)OC\C=C\c1ccccc1 |t:2,8| Show InChI InChI=1S/C25H24ClNO4/c1-3-20-23(25(30)31-14-8-11-17-9-5-4-6-10-17)22(18-12-7-13-19(26)15-18)21(24(28)29)16(2)27-20/h4-13,15,22,27H,3,14H2,1-2H3,(H,28,29)/b11-8+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus method |
Bioorg Med Chem Lett 18: 4813-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.096
BindingDB Entry DOI: 10.7270/Q208684R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227968
(CHEMBL310953)Show SMILES CC(C)OC(=O)C1=C(C)N=C(C)N(C1c1ccccc1[N+]([O-])=O)C(=O)OCCN(Cc1ccccc1)Cc1ccc2ccccc2c1 |c:6,t:9| Show InChI InChI=1S/C37H38N4O6/c1-25(2)47-36(42)34-26(3)38-27(4)40(35(34)32-16-10-11-17-33(32)41(44)45)37(43)46-21-20-39(23-28-12-6-5-7-13-28)24-29-18-19-30-14-8-9-15-31(30)22-29/h5-19,22,25,35H,20-21,23-24H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]- Nitrendipine binding to L-type calcium channels of rat cerebral cortex |
J Med Chem 32: 2399-406 (1989)
BindingDB Entry DOI: 10.7270/Q2GH9M57 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50306489
((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)Show SMILES CCCCCOC(=O)C1=C(C)N=C(C)C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OC |r,c:8,t:11| Show InChI InChI=1S/C21H26N2O6/c1-5-6-7-11-29-21(25)18-14(3)22-13(2)17(20(24)28-4)19(18)15-9-8-10-16(12-15)23(26)27/h8-10,12,17,19H,5-7,11H2,1-4H3/t17?,19-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.14 | n/a | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description
Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac membrane |
Bioorg Med Chem Lett 20: 805-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.104
BindingDB Entry DOI: 10.7270/Q26D5T3S |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227969
(CHEMBL312176 | CV-4093)Show SMILES CO\C(O)=C1/C(C(C(=O)OCCN2CCN(CC2)C(c2ccccc2)c2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:36,t:33| Show InChI InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,40H,17-22H2,1-3H3/b34-30- | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Biomedical Research
Curated by ChEMBL
| Assay Description
Inhibition of [3H]- Nitrendipine binding to L-type calcium channels of rat cerebral cortex |
J Med Chem 32: 2399-406 (1989)
BindingDB Entry DOI: 10.7270/Q2GH9M57 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475663
(CHEMBL202464)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccccc1)c1ccccc1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H23NO4/c1-16-20(23(26)27)22(19-13-7-4-8-14-19)21(17(2)25-16)24(28)29-15-9-12-18-10-5-3-6-11-18/h3-14,22,28H,15H2,1-2H3,(H,26,27)/b12-9+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229315
(CHEMBL312304)Show SMILES CCO\C(O)=C1\C(C(C(=O)OCC)=C(C)N=C1C[S+]([O-])c1ccccn1)c1ccccc1C(F)(F)F |c:15,t:12| Show InChI InChI=1S/C25H25F3N2O5S/c1-4-34-23(31)20-15(3)30-18(14-36(33)19-12-8-9-13-29-19)22(24(32)35-5-2)21(20)16-10-6-7-11-17(16)25(26,27)28/h6-13,21,32H,4-5,14H2,1-3H3/b24-22+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475664
(CHEMBL369934)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccccc1)c1cccc(Br)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H22BrNO4/c1-15-20(23(27)28)22(18-11-6-12-19(25)14-18)21(16(2)26-15)24(29)30-13-7-10-17-8-4-3-5-9-17/h3-12,14,22,29H,13H2,1-2H3,(H,27,28)/b10-7+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475672
(CHEMBL201057)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccccc1)c1cccc(I)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H22INO4/c1-15-20(23(27)28)22(18-11-6-12-19(25)14-18)21(16(2)26-15)24(29)30-13-7-10-17-8-4-3-5-9-17/h3-12,14,22,29H,13H2,1-2H3,(H,27,28)/b10-7+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475662
(CHEMBL201860)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OCc1ccc2ccccc2c1)c1cccc(Cl)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C26H22ClNO4/c1-15-22(25(29)30)24(20-8-5-9-21(27)13-20)23(16(2)28-15)26(31)32-14-17-10-11-18-6-3-4-7-19(18)12-17/h3-13,24,31H,14H2,1-2H3,(H,29,30)/b26-23+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50280077
(CHEMBL18988 | sec-Butyl-[4-(2,4-dimethoxy-phenyl)-...)Show SMILES CCC(C)NCc1ccc2C(Sc3ccccc3-n12)c1ccc(OC)cc1OC Show InChI InChI=1S/C24H28N2O2S/c1-5-16(2)25-15-17-10-13-21-24(19-12-11-18(27-3)14-22(19)28-4)29-23-9-7-6-8-20(23)26(17)21/h6-14,16,24-25H,5,15H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]nitrendipine from calcium channel receptor |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F47RB8 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50306489
((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)Show SMILES CCCCCOC(=O)C1=C(C)N=C(C)C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OC |r,c:8,t:11| Show InChI InChI=1S/C21H26N2O6/c1-5-6-7-11-29-21(25)18-14(3)22-13(2)17(20(24)28-4)19(18)15-9-8-10-16(12-15)23(26)27/h8-10,12,17,19H,5-7,11H2,1-4H3/t17?,19-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Fourth Military Medical University
Curated by ChEMBL
| Assay Description
Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cerebral cortex membrane |
Bioorg Med Chem Lett 20: 805-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.104
BindingDB Entry DOI: 10.7270/Q26D5T3S |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227617
(CHEMBL46635)Show SMILES CCOC(=O)CC1=C(C(\C(=C(/O)OCC)C(C)=N1)c1ccccc1C(F)(F)F)C(=O)OCC |c:16,t:6| Show InChI InChI=1S/C23H26F3NO6/c1-5-31-17(28)12-16-20(22(30)33-7-3)19(18(13(4)27-16)21(29)32-6-2)14-10-8-9-11-15(14)23(24,25)26/h8-11,19,29H,5-7,12H2,1-4H3/b21-18+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain. |
J Med Chem 31: 1659-64 (1988)
BindingDB Entry DOI: 10.7270/Q2WQ060D |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475669
(CHEMBL382072)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccccc1)c1cccc(Cl)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H22ClNO4/c1-15-20(23(27)28)22(18-11-6-12-19(25)14-18)21(16(2)26-15)24(29)30-13-7-10-17-8-4-3-5-9-17/h3-12,14,22,29H,13H2,1-2H3,(H,27,28)/b10-7+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475656
(CHEMBL201306)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccccc1)c1cccc(F)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H22FNO4/c1-15-20(23(27)28)22(18-11-6-12-19(25)14-18)21(16(2)26-15)24(29)30-13-7-10-17-8-4-3-5-9-17/h3-12,14,22,29H,13H2,1-2H3,(H,27,28)/b10-7+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475669
(CHEMBL382072)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccccc1)c1cccc(Cl)c1)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H22ClNO4/c1-15-20(23(27)28)22(18-11-6-12-19(25)14-18)21(16(2)26-15)24(29)30-13-7-10-17-8-4-3-5-9-17/h3-12,14,22,29H,13H2,1-2H3,(H,27,28)/b10-7+,24-21+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus method |
Bioorg Med Chem Lett 18: 4813-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.096
BindingDB Entry DOI: 10.7270/Q208684R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229269
(CHEMBL72696)Show SMILES CCO\C(O)=C1\C(C(C(=O)OCC)=C(C)N=C1C[S+]([O-])c1ccc(OC)cc1)c1ccccc1C(F)(F)F |c:15,t:12| Show InChI InChI=1S/C27H28F3NO6S/c1-5-36-25(32)22-16(3)31-21(15-38(34)18-13-11-17(35-4)12-14-18)24(26(33)37-6-2)23(22)19-9-7-8-10-20(19)27(28,29)30/h7-14,23,33H,5-6,15H2,1-4H3/b26-24+ | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229269
(CHEMBL72696)Show SMILES CCO\C(O)=C1\C(C(C(=O)OCC)=C(C)N=C1C[S+]([O-])c1ccc(OC)cc1)c1ccccc1C(F)(F)F |c:15,t:12| Show InChI InChI=1S/C27H28F3NO6S/c1-5-36-25(32)22-16(3)31-21(15-38(34)18-13-11-17(35-4)12-14-18)24(26(33)37-6-2)23(22)19-9-7-8-10-20(19)27(28,29)30/h7-14,23,33H,5-6,15H2,1-4H3/b26-24+ | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227621
(CHEMBL46452)Show SMILES CCO\C(O)=C1\[C@H]([C@H](C(=O)OCC)\C(=C\C(=O)c2ccncc2)N=C1C)c1ccccc1C(F)(F)F |c:24| Show InChI InChI=1S/C26H25F3N2O5/c1-4-35-24(33)21-15(3)31-19(14-20(32)16-10-12-30-13-11-16)23(25(34)36-5-2)22(21)17-8-6-7-9-18(17)26(27,28)29/h6-14,22-23,33H,4-5H2,1-3H3/b19-14-,24-21+/t22-,23-/m1/s1 | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain. |
J Med Chem 31: 1659-64 (1988)
BindingDB Entry DOI: 10.7270/Q2WQ060D |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229288
(CHEMBL75494)Show SMILES CCO\C(O)=C1\C(C(C(=O)OCC)=C(C)N=C1C[S+]([O-])c1ccccc1)c1ccccc1C(F)(F)F |c:15,t:12| Show InChI InChI=1S/C26H26F3NO5S/c1-4-34-24(31)21-16(3)30-20(15-36(33)17-11-7-6-8-12-17)23(25(32)35-5-2)22(21)18-13-9-10-14-19(18)26(27,28)29/h6-14,22,32H,4-5,15H2,1-3H3/b25-23+ | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227619
(CHEMBL44275)Show SMILES CCO\C(O)=C1\[C@H]([C@H](C(=O)OCC)\C(=C\C(=O)c2ccccc2)N=C1C)c1cccc(Cl)c1Cl |c:24| Show InChI InChI=1S/C26H25Cl2NO5/c1-4-33-25(31)21-15(3)29-19(14-20(30)16-10-7-6-8-11-16)23(26(32)34-5-2)22(21)17-12-9-13-18(27)24(17)28/h6-14,22-23,31H,4-5H2,1-3H3/b19-14-,25-21+/t22-,23-/m1/s1 | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain. |
J Med Chem 31: 1659-64 (1988)
BindingDB Entry DOI: 10.7270/Q2WQ060D |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101817
(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 | PDB
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TBA
| Assay Description
Inhibition of L-type calcium channel in Rattus norvegicus Wistar (rat) thoracic aorta assessed as relaxation of phenylephrine-induced vasoconstrictio... |
Citation and Details
Article DOI: 10.1007/s00044-011-9600-x
BindingDB Entry DOI: 10.7270/Q2XS5Z80 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50101817
(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 | PDB
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TBA
| Assay Description
Inhibition of L-type calcium channel in Rattus norvegicus Wistar (rat) thoracic aorta assessed as relaxation of phenylephrine-induced vasoconstrictio... |
Citation and Details
Article DOI: 10.1007/s00044-011-9600-x
BindingDB Entry DOI: 10.7270/Q2XS5Z80 |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50475661
(CHEMBL204486)Show SMILES CC1=NC(C)=C(C(\C1=C(/O)OC\C=C\c1ccccc1)c1ccccc1[N+]([O-])=O)C(O)=O |c:4,t:1| Show InChI InChI=1S/C24H22N2O6/c1-15-20(23(27)28)22(18-12-6-7-13-19(18)26(30)31)21(16(2)25-15)24(29)32-14-8-11-17-9-4-3-5-10-17/h3-13,22,29H,14H2,1-2H3,(H,27,28)/b11-8+,24-21+ | PDB
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Ajinomoto company Inc.
Curated by ChEMBL
| Assay Description
Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus method |
Bioorg Med Chem Lett 16: 798-802 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.021
BindingDB Entry DOI: 10.7270/Q2NP276R |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227627
(CHEMBL295323)Show SMILES CCO\C(O)=C1\[C@H]([C@H](C(=O)OCC)\C(=C\C(=O)c2ccccc2)N=C1C)c1ccccc1[N+]([O-])=O |c:24| Show InChI InChI=1S/C26H26N2O7/c1-4-34-25(30)22-16(3)27-19(15-21(29)17-11-7-6-8-12-17)24(26(31)35-5-2)23(22)18-13-9-10-14-20(18)28(32)33/h6-15,23-24,30H,4-5H2,1-3H3/b19-15-,25-22+/t23-,24-/m1/s1 | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain. |
J Med Chem 31: 1659-64 (1988)
BindingDB Entry DOI: 10.7270/Q2WQ060D |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50227615
(CHEMBL46590)Show SMILES CCO\C(O)=C1\[C@H]([C@H](C(=O)OCC)\C(=C\C(=O)c2ccc(cc2)N(C)C)N=C1C)c1ccccc1C(F)(F)F |c:27| Show InChI InChI=1S/C29H31F3N2O5/c1-6-38-27(36)24-17(3)33-22(16-23(35)18-12-14-19(15-13-18)34(4)5)26(28(37)39-7-2)25(24)20-10-8-9-11-21(20)29(30,31)32/h8-16,25-26,36H,6-7H2,1-5H3/b22-16-,27-24+/t25-,26-/m1/s1 | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain. |
J Med Chem 31: 1659-64 (1988)
BindingDB Entry DOI: 10.7270/Q2WQ060D |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229332
(CHEMBL72341)Show SMILES CCO\C(O)=C1\C(C(C(=O)OCC)=C(C)N=C1CSc1ccncc1)c1ccccc1C(F)(F)F |c:15,t:12| Show InChI InChI=1S/C25H25F3N2O4S/c1-4-33-23(31)20-15(3)30-19(14-35-16-10-12-29-13-11-16)22(24(32)34-5-2)21(20)17-8-6-7-9-18(17)25(26,27)28/h6-13,21,32H,4-5,14H2,1-3H3/b24-22+ | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229310
(CHEMBL73583)Show SMILES CCO\C(O)=C1\C(C(C(=O)OC)=C(C)N=C1CSc1ccccc1Cl)c1ccccc1C(F)(F)F |c:14,t:11| Show InChI InChI=1S/C25H23ClF3NO4S/c1-4-34-24(32)22-18(13-35-19-12-8-7-11-17(19)26)30-14(2)20(23(31)33-3)21(22)15-9-5-6-10-16(15)25(27,28)29/h5-12,21,32H,4,13H2,1-3H3/b24-22+ | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50229270
(CHEMBL306566)Show SMILES CCO\C(O)=C1\C(C(C(=O)OCC)=C(C)N=C1C[S+]([O-])c1ccncc1)c1ccccc1C(F)(F)F |c:15,t:12| Show InChI InChI=1S/C25H25F3N2O5S/c1-4-34-23(31)20-15(3)30-19(14-36(33)16-10-12-29-13-11-16)22(24(32)35-5-2)21(20)17-8-6-7-9-18(17)25(26,27)28/h6-13,21,32H,4-5,14H2,1-3H3/b24-22+ | PDB
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Warner-Lambert Company
Curated by ChEMBL
| Assay Description
Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipine |
J Med Chem 34: 2248-60 (1991)
BindingDB Entry DOI: 10.7270/Q27P91MK |
More data for this
Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1S
(Rattus norvegicus) | BDBM50004704
((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)Show SMILES COc1ccc(cc1)[C@@H]1Sc2ccccc2N(CCN(C)C)C(=O)[C@@H]1OC(C)=O |r| Show InChI InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1 | PDB
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TBA
| Assay Description
Displacement of [3H]nitrendipine from calcium channel receptor |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F47RB8 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
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